ME/CFS: when exhaustion is more than just tiredness

Feeling tired is normal. However, in the case of myalgic encephalomyelitis (chronic fatigue syndrome), exhaustion is not a temporary condition, but rather a defining feature of the disease. The condition is not very visible – and that is precisely why it is often difficult to diagnose.

Sergei Fink

23 June 2026

A man lies on a pillow with his eyes closed, as if he were asleep. The image is blurred at the edges, creating a dreamy, surreal effect with cool blue and white tones.
The body lies still, but rest remains elusive. (Image: Adobe Stock)

Exhaustion is something many people experience following periods of stress, illness, or due to lack of sleep. As a rule, however, the body recovers. This is not the case with ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome). The condition is chronic and can severely restrict people’s ability to function in their daily lives. Those affected describe a deep physical and mental exhaustion that does not get better even with rest. Even minor stress can bring about a noticeable deterioration.  

When stress becomes a problem
A typical symptom of ME/CFS is what is known as post-exertional malaise. Physical or mental exertion, and sometimes emotional stress, does not stimulate activity but rather leads to a decline in performance. The effects can last for hours, days or even longer.

Commonly reported symptoms include:  

  • severe fatigue 
  • difficulty concentrating and recalling information 
  • non-restorative sleep  
  • pain 
  • sensitivity to light, noise, or touch.
     

Difficult to diagnose
ME/CFS is generally not visible outwardly. Laboratory results and imaging scans often fail to provide clear evidence. This makes establishing a diagnosis difficult and often leads to prolonged investigations.  

For those affected, this means:  

  • partial or complete inability to work.
  • adjustments to everyday life
  • need to explain symptoms to colleagues and employers.

Although there is currently no way of treating the cause of the condition, it is important to obtain an accurate diagnosis. This can help you to avoid becoming overwhelmed and adapt to living with the condition. Careful and consistent management of energy levels can help prevent excessive strain. It is also advisable to maintain a regular sleep pattern and fixed rest periods, even if you are currently feeling well.  

Please note: This article is for general information purposes only and is not intended to be a substitute for medical advice.  

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